Zum Hauptinhalt springen
Dieser Inhalt ist noch nicht in Ihrer Sprache verfügbar und wird auf Englisch angezeigt.

Medchem

Skill Verifiziert Aktiv

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Zweck

To efficiently screen and prioritize compound libraries in drug discovery by applying established medicinal chemistry rules and filters.

Funktionen

  • Apply drug-likeness rules (Lipinski, Veber, Oprea)
  • Filter by structural alerts and PAINS patterns
  • Detect chemical groups and functional moieties
  • Calculate molecular complexity metrics
  • Apply custom property-based constraints

Anwendungsfälle

  • Applying drug-likeness rules to compound libraries
  • Filtering molecules by structural alerts or PAINS patterns
  • Prioritizing compounds for lead optimization
  • Detecting reactive or problematic functional groups

Nicht-Ziele

  • Providing definitive pass/fail judgments on drug viability
  • Replacing expert domain knowledge
  • Predicting in vivo properties beyond rule-based assessments

Installation

npx skills add K-Dense-AI/claude-scientific-skills

Führt das Vercel skills CLI (skills.sh) via npx aus — benötigt Node.js lokal und mindestens einen installierten skills-kompatiblen Agent (Claude Code, Cursor, Codex, …). Setzt voraus, dass das Repo dem agentskills.io-Format folgt.

Qualitätspunktzahl

Verifiziert
99 /100
Analysiert 1 day ago

Vertrauenssignale

Letzter Commit3 days ago
Sterne21k
LizenzApache-2.0
Status
Quellcode ansehen

Ähnliche Erweiterungen

Medchem Filters

96

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering. Part of the AlterLab Academic Skills suite.

Skill
AlterLab-IEU

AlterLab PDB Access

99

Access RCSB PDB for 3D protein/nucleic acid structures. Search by text/sequence/structure, download coordinates (PDB/mmCIF), retrieve metadata, for structural biology and drug discovery. Part of the AlterLab Academic Skills suite.

Skill
AlterLab-IEU

RDKit Cheminformatics Toolkit

99

Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

Skill
K-Dense-AI

PyTDC (Therapeutics Data Commons)

99

Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.

Skill
K-Dense-AI

Molfeat

99

Molecular featurization for ML (100+ featurizers). ECFP, MACCS, descriptors, pretrained models (ChemBERTa), convert SMILES to features, for QSAR and molecular ML.

Skill
K-Dense-AI

Deepchem

99

Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.

Skill
K-Dense-AI