Email Best Practices

Prepare an organisation for regulatory inspection by assessing readiness against agency-specific focus areas (FDA, EMA, MHRA). Covers warning letter and 483 theme analysis, mock inspection protocols, document bundle preparation, inspection logistics, and response template creation. Use when a regulatory inspection has been announced or is anticipated, when a periodic self-assessment is due, when new systems have been implemented since the last inspection, or after a significant audit finding that may attract regulatory attention.

Design and operate a data integrity monitoring programme based on ALCOA+ principles. Covers detective controls, audit trail review schedules, anomaly detection patterns (off-hours activity, sequential modifications, bulk changes), metrics dashboards, investigation triggers, and escalation matrix definition. Use when establishing a data integrity monitoring programme for GxP systems, preparing for inspections where data integrity is a focus area, after a data integrity incident requiring enhanced monitoring, or when implementing MHRA, WHO, or PIC/S guidance.

Investigate root causes and manage CAPAs (Corrective and Preventive Actions) for compliance deviations. Covers investigation method selection (5-Why, fishbone, fault tree), structured root cause analysis, corrective vs preventive action design, effectiveness verification, and trend analysis. Use when an audit finding requires a CAPA, when a deviation or incident occurs in a validated system, when a regulatory observation needs a formal response, when a data integrity anomaly requires investigation, or when recurring issues suggest a systemic root cause.

Master skill for legal teams using Claude. Loads the right reference for the user's question (privilege configuration, MCP hardening, verification, long documents, practice-area patterns, skill authoring) and routes to specialized starter skills (NDA triage, version diff, meeting brief, citation verification, status synthesis). Auto-invokes when the user mentions legal work, contracts, redlines, NDAs, privilege, attorney-client, court filings, depositions, regulatory compliance, or asks how to set up Claude for a law firm or in-house legal team.

Evolution Engine 的领域知识 — 支持 LLM 从原始 OHLCV 数据中自主发现策略。涵盖生成-回测-选择-进化循环、向量化回测、样本外验证和策略梯度。在发现交易模式、运行回测、进化策略或审查进化日志时使用。由“evolve”、“discover patterns”、“backtest”、“evolution”、“strategy generation”、“candidate strategy”触发。

使用并行子代理军队管理 context-mode GitHub 问题、PR、发布和营销。为每个任务编排 10-20 个动态代理。在分类问题、审查 PR、发布版本、撰写 LinkedIn 帖子、宣布发布、修复错误、合并贡献、验证 ENV 变量、测试适配器或同步分支时使用。